Experimental allergic neuritis: a new experimental approach.

Experimental allergic neuritis-like disease in rabbits after injection with influenza vaccines mixed with gangliosides and adjuvants.

An experimental allergic neuritis-like disease was induced in rabbits 3 to 8 weeks after injection with large doses of influenza vaccines mixed with gangliosides, cholesterol, and Freund complete adjuvant. The inclusion of gangliosides was essential to induce the experimental allergic neuritis-like disease. In trials with six different lots of vaccine, both swine influenza and non-swine influen...

Autoimmune diseases and thalidomide. I. Experimental allergic encephalomyelitis and experimental allergic neuritis of the guinea pig.

The teratogenic effect of thalidomide (Th) is well-known. Current theories about the mechanism of action of this effect have been well summarized by Woollam (21), There is controversy about the possible immunosuppressive action of this compound (1 , 2,4,5, 10) and its influence on chromosome aberrations (9. 14. 15). It seems clear, however, that the drug does not have an all-inclusive "blanket"...

Changes in Nerve Conduction in Experimental Allergic Neuritis.

Suppression of experimental allergic neuritis with P2 protein of PNS myelin.

Experimental allergic neuritis was induced in the guinea pig with bovine PNS myelin. Treatment with P2 protein at the onset of the disease markedly reduced the severity of the clinical signs compared with untreated controls and animals treated with CNS myelin basic protein. The mortality was reduced from 94% in the combined control group to 50% in the treated group. Saline was a better vehicle ...

Effects of plasmapheresis on the course of experimental allergic neuritis in rabbits.

Experimental allergic neuritis was induced in 30 rabbits with extract of bovine peripheral nerve in complete Freund's adjuvant. Of the 22 animals that completed the study, nine animals were plasmapheresed within two weeks of inoculation and 13 animals served as controls. The plasmapheresed animals developed a less severe form of EAN than the controls. Differences were apparent in clinical weakn...